Answer
Yes! Hive Radiator Valves are compatible with multizone heating installations, where each zone is controlled by a separate thermostat.
If you have Hive Multizone heating, you can link each Hive Radiator Valve to a specific thermostat. Heat On Demand will only boost the heating in the zone linked to the Hive Radiator Valve that needs heat (e.g., your “upstairs” thermostat, if a bedroom radiator needs to warm up).